In Jamaica, the recreational use of cannabis was decriminalized ten years ago, ushering in legal production and sale for medical purposes. However, despite the region's historical connection to cannabis cultivation, regulatory challenges hinder its growth as a leading cannabis producer. The impact of U.S. drug policy has influenced legislation across the Caribbean, preventing a more robust cannabis industry from taking root. In Antigua and Barbuda, the government is actively pursuing the establishment of an export industry, capitalizing on its favorable geographical location and existing legal framework. Yet, high operational costs and restrictions on sales for non-medical use are major obstacles affecting both countries. Consequently, illegal cannabis suppliers continue to dominate the market, underlining the need for further liberalization in the cannabis industry. Enhancing legislation can unlock significant socio-economic benefits, especially within communities historically involved in cannabis cultivation. As attitudes shift toward legalization, local producers are increasingly hopeful for improved profitability and market access internationally.