In a late afternoon NFL matchup on Sunday, November 12, 2025, the San Francisco 49ers defeated the Arizona Cardinals decisively with a final score of 41-22. San Francisco's quarterback Brock Purdy made a strong return from injury, showcasing his skills by throwing three touchdown passes and completing 19 of 26 attempts for a total of 200 yards. Furthermore, All-Pro running back Christian McCaffrey significantly contributed to the team's victory by scoring two rushing touchdowns and one receiving touchdown, along with an impressive 81 rushing yards. On the other side, the Arizona Cardinals, led by quarterback Jacoby Brissett, struggled despite his record-breaking performance where he set a new NFL record for completions in a game with 47. Brissett completed 47 of 57 passes for 452 yards, including two touchdowns, but his impressive stats came during garbage time when the team's fate was already sealed. The Cardinals had fallen behind substantially in the third quarter, trailing 35-10, causing Brissett to attempt to rally the team with high-volume passing. The loss for Arizona marked another notch in a disappointing season as they dropped to a 3-7 record. Notably, the team also set an unlikely franchise record by committing 17 penalties for a total of 130 yards, surpassing a record that stood since 1936. This sloppiness has been a continuing theme in the Cardinals' season, demonstrating the struggles they have faced as they fell further behind in NFC playoff contention. Looking forward, both teams will need to regroup quickly; the 49ers, now with a 7-4 record, aim to build momentum in the playoff race as they prepare to face the Carolina Panthers on Monday Night Football. In contrast, the Cardinals must move on from this defeat to prepare for a challenging Week 12 matchup against the Jacksonville Jaguars. The win for the 49ers highlights their offensive capability, while the Cardinals are left to ponder a season that has not gone as planned.